When planning treatment for Graves’ disease with ¹³¹I, the effective half-life (T_eff) should be estimated individually as it depends on biological characteristics such as iodine uptake and excretion, which differ from an individual to another (Berg et al. 1996). All the methods to quantify T_eff described in the literature are quite complex and are difficult to be used in clinical routine. With the aim of optimizing this process, a simplified method is proposed here to evaluate T_eff of ¹³¹I during treatment of Graves’ disease. The present study suggests improving the method of determining T_eff based on thermoluminescence dosimetry. This involves implementing a new method and includes reduction of TLD (Thermoluminescent Dosimeter) measurements. The proposed method was validated on patients with Graves’ disease. The radiation dose delivered to the patients was determined using the MIRD (Medical Internal Radiation Dosimetry) formalism. The relative difference between T_eff obtained based on seven measurement intervals at [0–24 h, 24–48 h, 48–72 h, 72–96 h, 96–120 h, 120–144 h, 144–168 h] and based on three measurement intervals at [0–24 h, 72–96 h, 144–168 h] and [0–24 h, 120–144 h, 144–168 h] was 1.9% and 3.81%, respectively. Comparison of doses obtained based on a general T_eff and on a personalized T_eff gave a statistically significant difference with a correlation coefficient R²of 0.44. The T_eff obtained from just three measurements was found to be sufficiently accurate and easily applicable. The results obtained demonstrate the need to determine and use personalized T_eff values instead of using a fixed value of 7 days.

当计划用¹³¹ I治疗 Graves 病时，应单独估计有效半衰期 ( T _eff )，因为它取决于生物特征，例如碘摄取和排泄，这些特征因人而异（Berg 等人，1996 年） ）。文献中描述的所有量化T _eff的方法都非常复杂，难以在临床常规中使用。以优化这个过程的目的，简化的方法在这里提出，以评估Ť _EFF的¹³¹治疗格雷夫斯病的过程中予。本研究建议改进确定T _eff的方法基于热释光剂量法。这涉及实施一种新方法，包括减少 TLD（热致发光剂量计）测量。所提出的方法在格雷夫斯病患者身上得到了验证。使用 MIRD（医学内部辐射剂量测定法）形式确定递送给患者的辐射剂量。之间的相对差Ť _EFF获得基于在[0-24小时，24-48小时，48-72小时，72-96小时，96-120小时，120-144小时，144-168 H]和七个测量间隔基于 [0-24 小时、72-96 小时、144-168 小时]和 [0-24 小时、120-144 小时、144-168 小时]的三个测量间隔，分别为 1.9% 和 3.81%。基于一般T _eff和个性化T _eff获得的剂量比较给出了统计学上显着的差异，相关系数R ²为 0.44。发现仅从三个测量中获得的T _eff足够准确且易于应用。获得的结果表明需要确定和使用个性化的T _eff值，而不是使用 7 天的固定值。