Targeted delivery and controlled release of drugs has been considered to be an important therapeutic approach since it could allow a better treatment efficiency and less side effects. In this research, magnetite Fe₃O₄ nanoparticles were successfully synthesized via the coprecipitation method and then loaded in alginate beads with berberine as a drug model for drug release application. Various factors such as pH values of the suspended environment and surface modifications of the drug carrier could be exploited to adjust the amount of drug release. More importantly, the amount of drug release could be effectively controlled by an on-off switching operation of a static magnetic field.

中文翻译：

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从磁性纳米颗粒藻酸盐珠按需释放药物。

靶向递送和药物的控释被认为是一种重要的治疗方法，因为它可以带来更好的治疗效率和更少的副作用。在这项研究中，通过共沉淀法成功合成了磁铁矿Fe ₃ O ₄纳米粒子，然后将其与黄连素一起装入藻酸盐珠粒中，作为药物释放应用的药物模型。可以利用诸如悬浮环境的pH值和药物载体的表面改性的各种因素来调节药物释放的量。更重要的是，可以通过静磁场的开-关切换操作来有效地控制药物释放的量。