Targeted delivery and controlled release of drugs has been considered to be an important therapeutic approach since it could allow a better treatment efficiency and less side effects. In this research, magnetite Fe₃O₄ nanoparticles were successfully synthesized via the coprecipitation method and then loaded in alginate beads with berberine as a drug model for drug release application. Various factors such as pH values of the suspended environment and surface modifications of the drug carrier could be exploited to adjust the amount of drug release. More importantly, the amount of drug release could be effectively controlled by an on-off switching operation of a static magnetic field.

中文翻译：

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从负载磁性纳米粒子的藻酸盐珠中按需释放药物


药物的靶向递送和控释被认为是一种重要的治疗方法，因为它可以实现更好的治疗效率和更少的副作用。本研究通过共沉淀法成功合成了磁铁矿Fe ₃ O ₄纳米颗粒，然后将其负载到含有小檗碱的海藻酸钠微珠中，作为药物释放应用的药物模型。可以利用悬浮环境的pH值和药物载体的表面修饰等各种因素来调节药物释放量。更重要的是，通过静磁场的开关操作可以有效地控制药物释放量。