With the help of computational fluid dynamics (CFD), hemodynamics of the pulmonary arteries (PA’s) can be studied in detail and varying physiological circumstances and treatment options can be simulated. This offers the opportunity to improve the diagnostics and treatment of PA stenosis in biventricular congenital heart disease (CHD). The aim of this review was to evaluate the methods of computational studies for PA’s in biventricular CHD and the level of validation of the numerical outcomes. A total of 34 original research papers were selected. The literature showed a great variety in the used methods for (re) construction of the geometry as well as definition of the boundary conditions and numerical setup. There were 10 different methods identified to define inlet boundary conditions and 17 for outlet boundary conditions. A total of nine papers verified their CFD outcomes by comparing results to clinical data or by an experimental mock loop. The diversity in used methods and the low level of validation of the outcomes result in uncertainties regarding the reliability of numerical studies. This limits the current clinical utility of CFD for the study of PA flow in CHD. Standardization and validation of the methods are therefore recommended.

中文翻译：

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先天性心脏病肺动脉的计算分析：方法和结果的回顾

在计算流体动力学 (CFD) 的帮助下，可以详细研究肺动脉 (PA) 的血流动力学，并可以模拟不同的生理环境和治疗方案。这为改进双心室先天性心脏病 (CHD) 中 PA 狭窄的诊断和治疗提供了机会。本综述的目的是评估双心室 CHD 中 PA 的计算研究方法和数值结果的验证水平。共评选出34篇原创研究论文。文献显示用于（重新）构建几何形状以及定义边界条件和数值设置的方法多种多样。确定了 10 种不同的方法来定义入口边界条件，17 种方法用于定义出口边界条件。共有 9 篇论文通过将结果与临床数据进行比较或通过实验模拟循环验证了他们的 CFD 结果。所用方法的多样性和结果的低水平验证导致数值研究可靠性的不确定性。这限制了 CFD 目前用于研究 CHD 中 PA 流量的临床效用。因此建议对方法进行标准化和验证。