Correlation of serum cystatin C with inflammatory cytokines in patients with traumatic brain injury,SYNAPSE

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Correlation of serum cystatin C with inflammatory cytokines in patients with traumatic brain injury
SYNAPSE ( IF 1.6 ) Pub Date : 2021-04-02 , DOI: 10.1002/syn.22201
Jingrong Zou ₁ , Haitao Sun ₁ , Yang Xiang ₁

Affiliation

Traumatic brain injury (TBI) is a world-wide leading health problem with high morbidity and mortality rates. Emerging studies have demonstrated that TBI is the consequence of a series of inflammatory responses in the body. The alteration of Cystatin C (Cys C) was reported in a variety of chronic inflammatory diseases and was also recommended as a biomarker for predicting renal diseases. In this study, we aimed to investigate the relationship between serum Cys C and TBI, and to evaluate the prognostic role of Cys C in TBI prediction. One hundred and seventy-six patients with TBI were recruited and 102 patients were finally analyzed, with 30 healthy control subjects. The concentrations of Cys C were significantly reduced in the healthy control group compared to the TBI group, and correlated with high GCS scores. The levels of hsCRP, counts of white blood cells, and levels of IL-6 and TNF-α were remarkably elevated in the TBI patients compared with the control group in a severity-dependent manner. Moreover, the concentration of Cys C was negatively correlated with TBI severity and positively correlated with inflammatory factors. In conclusion, serum Cys is an inflammatory cytokine-related factor and might indicate the severity of TBI thus serving as a prognostic biomarker.

中文翻译：

脑外伤患者血清胱抑素C与炎性细胞因子的相关性

创伤性脑损伤 (TBI) 是世界范围内的主要健康问题，发病率和死亡率都很高。新兴研究表明，TBI 是体内一系列炎症反应的结果。在多种慢性炎症性疾病中报道了胱抑素 C (Cys C) 的改变，并且还被推荐作为预测肾脏疾病的生物标志物。在本研究中，我们旨在研究血清 Cys C 与 TBI 之间的关系，并评估 Cys C 在 TBI 预测中的预后作用。招募了 176 名 TBI 患者，最终分析了 102 名患者，其中健康对照者 30 名。与 TBI 组相比，健康对照组的 Cys C 浓度显着降低，并且与高 GCS 评分相关。hsCRP 水平，与对照组相比，TBI 患者的白细胞计数、IL-6 和 TNF-α 水平显着升高，且呈严重程度依赖性。此外，Cys C 浓度与 TBI 严重程度呈负相关，与炎症因子呈正相关。总之，血清 Cys 是一种炎症细胞因子相关因子，可能表明 TBI 的严重程度，因此可作为预后生物标志物。

更新日期：2021-04-02

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