We understand little of the pathogenesis of developmental cortical lesions, because we understand little of the diversity of the cell types that contribute to the diseases or how those cells interact. We tested the hypothesis that cellular diversity and cell–cell interactions play an important role in these disorders by investigating the signalling molecules in the commonest cortical malformations that lead to childhood epilepsy, focal cortical dysplasia (FCD) and tuberous sclerosis (TS).

中文翻译：

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识别大脑发育障碍中的细胞信号分子：来自局灶性皮质发育不良和结节性硬化症的证据

我们对发育性皮层病变的发病机制知之甚少，因为我们对导致疾病的细胞类型的多样性或这些细胞如何相互作用知之甚少。我们通过研究导致儿童癫痫、局灶性皮质发育不良 (FCD) 和结节性硬化症 (TS) 的最常见皮质畸形中的信号分子，验证了细胞多样性和细胞间相互作用在这些疾病中起重要作用的假设。