Despite recent improvement in implant survival rates, there remains a significant demand for enhancing the long-term clinical efficacy of titanium (Ti) implants, particularly for the prevention of peri-implantitis. Bioactive substances such as antimicrobial peptides are emerging as effective alternatives for contemporary antimicrobial agents used in dental health care. Current research work was focused to use laterosporulins that are non-haemolytic cationic antimicrobial peptides from Brevibacillus spp. for coating commercially available Ti discs. The coated Ti surfaces were evaluated in vitro for biofilm formation by two dental plaque isolates Streptococcus gordonii strain DIGK25 and S. mutans strain DIGK119 as representatives of commensal and pathogenic streptococci respectively. The biofilm inhibition was ascertained with replicated experiments on hydroxyapatite discs and confirmed by florescence microscopy. The laterosporulin coated Ti discs showed significantly reduced biofilm formation by oral streptococci and displayed promising potential to enhance the antibacterial surface properties. Such improvised Ti surfaces may curb the menace of oral streptococcal biofilm formation on dental implants and the associated implant failures.

尽管最近种植体存活率有所提高，但对于提高钛 (Ti) 种植体的长期临床疗效，特别是在预防种植体周围炎方面仍然存在很大的需求。诸如抗菌肽之类的生物活性物质正在成为牙科保健中使用的当代抗菌剂的有效替代品。目前的研究工作集中在使用侧孢菌素，它是来自短杆菌属的非溶血性阳离子抗菌肽。用于涂覆市售的钛盘。通过两种牙菌斑分离株Streptococcus gordonii菌株 DIGK25 和S. mutans 在体外评估涂覆的 Ti 表面的生物膜形成菌株 DIGK119 分别代表共生链球菌和致病链球菌。通过对羟基磷灰石圆​​片的重复实验确定生物膜抑制，并通过荧光显微镜确认。涂有侧孢菌素的钛圆片显示出口腔链球菌形成的生物膜显着减少，并显示出增强抗菌表面特性的有希望的潜力。这种临时的钛表面可以抑制口腔链球菌生物膜在牙种植体上形成的威胁以及相关的种植体失败。