Background: Craniopharyngioma (CP), despite being a malformational tumor of low histological grade, causes considerable morbidity and mortality mostly due to hypothalamo-pituitary dysfunction that is created by tumor itself or its treatment. Summary: Fluid-electrolyte disturbances which range from dehydration to fluid overload and from hypernatremia to hyponatremia are frequently encountered during the acute postoperative period and should be carefully managed to avoid permanent neurological sequelae. Hypopituitarism, increased cardiovascular risk, hypothalamic damage, hypothalamic obesity, visual and neurological deficits, and impaired bone health and cognitive function are the morbidities affecting the well-being of these patients in the long term. Key Messages: Timely and optimal treatment of early postoperative and long-term complications of CP is crucial for preserving quality of life of these patients.
Horm Res Paediatr

中文翻译：

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颅咽管瘤术后及远期内分泌并发症

背景：颅咽管瘤 (CP) 尽管是一种低组织学分级的畸形肿瘤，但由于肿瘤本身或其治疗造成的下丘脑-垂体功能障碍，导致相当大的发病率和死亡率。总结：从脱水到液体超负荷以及从高钠血症到低钠血症的液体电解质紊乱在术后急性期经常遇到，应小心处理以避免永久性神经系统后遗症。从长远来看，垂体功能减退、心血管风险增加、下丘脑损伤、下丘脑肥胖、视觉和神经功能障碍以及骨骼健康和认知功能受损是影响这些患者健康的疾病。关键信息：CP 术后早期和长期并发症的及时和最佳治疗对于保持这些患者的生活质量至关重要。
儿科荷尔蒙