Dynamic interplay between cell membrane tension and clathrin-mediated endocytosis,Biology of the Cell

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Dynamic interplay between cell membrane tension and clathrin-mediated endocytosis
Biology of the Cell ( IF 2.4 ) Pub Date : 2021-03-31 , DOI: 10.1111/boc.202000110
Umidahan Djakbarova ₁ , Yasaman Madraki ₁ , Emily T Chan _{2,

3} , Cömert Kural _{1,

2}

Affiliation

Deformability of the plasma membrane, the outermost surface of metazoan cells, allows cells to be dynamic, mobile and flexible. Factors that affect this deformability, such as tension on the membrane, can regulate a myriad of cellular functions, including membrane resealing, cell motility, polarisation, shape maintenance, membrane area control and endocytic vesicle trafficking. This review focuses on mechanoregulation of clathrin-mediated endocytosis (CME). We first delineate the origins of cell membrane tension and the factors that yield to its spatial and temporal fluctuations within cells. We then review the recent literature demonstrating that tension on the membrane is a fast-acting and reversible regulator of CME. Finally, we discuss tension-based regulation of endocytic clathrin coat formation during physiological processes.

中文翻译：

细胞膜张力与网格蛋白介导的内吞作用之间的动态相互作用

质膜是后生动物细胞的最外层表面，其可变形性使细胞具有动态性、移动性和灵活性。影响这种变形性的因素，例如膜上的张力，可以调节多种细胞功能，包括膜重新密封、细胞运动、极化、形状维持、膜面积控制和内吞囊泡运输。本综述重点关注网格蛋白介导的内吞作用（CME）的机械调节。我们首先描述细胞膜张力的起源以及导致细胞内时空波动的因素。然后，我们回顾了最近的文献，证明膜上的张力是 CME 的快速作用和可逆调节剂。最后，我们讨论了生理过程中内吞网格蛋白外壳形成的基于张力的调节。

更新日期：2021-03-31

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