A Close‐to‐Aromatize Approach for the Late‐Stage Functionalization through Ring Closing Metathesis,Helvetica Chimica Acta

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A Close‐to‐Aromatize Approach for the Late‐Stage Functionalization through Ring Closing Metathesis
Helvetica Chimica Acta ( IF 1.5 ) Pub Date : 2021-04-01 , DOI: 10.1002/hlca.202100024
Boris Lozhkin ₁ , Thomas R. Ward ₂

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An efficient approach for the synthesis of monosubstituted aromatic compounds relying on a ring‐closing metathesis followed by spontaneous 1,2‐elimination is presented. The efficiency for late‐stage functionalization is highlighted in various solvents (up to 920 TON). This approach is compatible with strained cycles and other multiple bonds in the substrate.

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