Critical overview on the green synthesis of carbon quantum dots and their application for cancer therapy,Environmental Science: Nano

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Critical overview on the green synthesis of carbon quantum dots and their application for cancer therapy
Environmental Science: Nano ( IF 5.8 ) Pub Date : 2021-3-10 , DOI: 10.1039/d1en00017a
Liam Joseph Desmond _{1,

2,

3,

4} , Anh N. Phan _{1,

2,

3,

4} , Piergiorgio Gentile _{1,

2,

3,

4}

Affiliation

Cancer therapeutic systems can help to confront and overcome many different strands of tumours in clinical patients. Despite the benefits, current therapeutic systems present clear unmet challenges, such as their toxicity and damaging effects to human body cells and the host. The need for easy-to-fabricate, safe and non-toxic therapeutic systems has driven the research field towards the use of carbon quantum dots. Their bioimaging with green, non-toxic, biocompatible and attractive quantum properties present them as distinctively advantageous over conventional/metal-based quantum dots. In this review, the current progress in the development of quantum dots, focusing on carbon quantum dots for use in nanotheranostics for different tumours, will be critically analysed. The advantages of applying carbon quantum dots by green bottom-up approaches into nanotherapy systems will be highlighted. Finally, ongoing challenges and opportunities associated with a green and sustainable synthesis of carbon quantum dots with specific functional groups to aid the next stages in the development of the nanotherapy system will also be discussed.

中文翻译：

碳量子点的绿色合成及其在癌症治疗中的应用的重要概述

癌症治疗系统可以帮助应对和克服临床患者的许多不同的肿瘤。尽管有这些好处，当前的治疗系统仍存在明显的尚未解决的挑战，例如它们对人体细胞和宿主的毒性和破坏作用。对易于制造，安全和无毒的治疗系统的需求已将研究领域推向了使用碳量子点的领域。它们具有绿色，无毒，生物相容性和有吸引力的量子特性的生物成像使它们与常规/基于金属的量子点相比具有明显的优势。在这篇综述中，将重点分析量子点开发的当前进展，重点是针对用于不同肿瘤的纳米热学中的碳量子点。将强调通过绿色自下而上的方法将碳量子点应用于纳米治疗系统的优势。最后，还将讨论与绿色和可持续合成具有特定官能团的碳量子点相关的挑战和机遇，以帮助纳米治疗系统发展的下一阶段。

更新日期：2021-04-01

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