Background: Gastrointestinal stromal tumor (GIST) of the ampulla of Vater is a rare occurrence. To the best of our knowledge, there has been no published review on this rare tumor in the English literature so far. Summary: In this review, we will discuss all the reported details of the published cases, including demography, clinical presentation, imaging, gross pathology and histopathology, immunohistochemical findings, treatment modalities, and outcome of cases with the diagnosis GIST from the ampulla of Vater in the last 20 years. Key Message: Twenty-five cases of GIST in the ampulla of Vater have been reported in the last 20 years in the English literature. GIST in the ampulla of Vater are usually small tumors (#x3c;5 cm) in middle-age patients. The majority of the patients present with lower GI bleeding and abdominal pain. Imaging findings are not characteristic, and most of the patients without biopsy and with no histologic diagnosis were operated with the primary impression of adenocarcinoma, neuroendocrine tumor, and GIST. Perioperative tissue biopsy has been accurate in #x3c;70% of the cases. The majority of the reported cases of GISTs in the ampulla of Vater have been low risk with spindle-cell morphology, low mitotic figures, and minimal atypia; reactive for C-KIT and DOG-1; and nonreactive for SMA, desmin, and S100. In the majority of the cases, duodenectomy with or without Whipple’s operation has been performed, and most of the cases showed good prognosis.
Gastrointest Tumors

中文翻译：

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法特壶腹胃肠道间质瘤：叙事回顾

背景： Vater 壶腹的胃肠道间质瘤 (GIST) 罕见。据我们所知，到目前为止，英语文献中还没有关于这种罕见肿瘤的发表评论。摘要：在这篇综述中，我们将讨论已发表病例的所有报告细节，包括人口学、临床表现、影像学、大体病理学和组织病理学、免疫组化结果、治疗方式以及从 Vater 壶腹诊断为 GIST 的病例的结果在过去的 20 年里。关键信息：在过去的 20 年中，英国文献报道了 25 例 Vater 壶腹的 GIST 病例。Vater 壶腹的 GIST 通常是中年患者的小肿瘤 (#x3c;5 cm)。大多数患者出现下消化道出血和腹痛。影像学表现不具特征性，大多数未进行活检且未进行组织学诊断的患者以腺癌、神经内分泌肿瘤和 GIST 为主要印象进行手术。#x3c;70% 的病例围手术期组织活检准确无误。大多数报告的 Vater 壶腹 GIST 病例的风险较低，具有梭形细胞形态、低有丝分裂象和极少的异型性；对 C-KIT 和 DOG-1 起反应；对 SMA、desmin 和 S100 无反应。在大多数情况下，
胃肠肿瘤