Temporal lobe epilepsy (TLE) is considered to be the most common form of epilepsy, and it has been seen that most patients are refractory to antiepileptic drugs. A strong association of this ailment has been established with psychiatric comorbidities, primarily mood and anxiety disorders. The side of epileptogenic may contribute to depressive and anxiety symptoms; thus, in this study, we performed a systematic review to evaluate the prevalence of depression in TLE in surgical patients. The literature search was performed using PubMed/Medline, Web of Science, and PsycNet to gather data from inception until January 2019. The search strategy was related to TLE, depressive disorder, and anxiety. After reading full texts, 14 articles meeting the inclusion criteria were screened. The main method utilized for psychiatric diagnosis was Diagnostic and Statistical Manual of Mental Disorders/Structured Clinical Interview for DSM. However, most studies failed to perform the neuropsychological evaluation. For those with lateralization of epilepsy, focus mostly occurred in the left hemisphere. For individual depressive diagnosis, 9 studies were evaluated, and 5 for anxiety. Therefore, from the data analyzed in both situations, no diagnosis was representative in preoperative and postoperative cases. In order to estimate the efficacy of surgery in the psychiatry episodes and its relation to seizure control, the risk of depression and anxiety symptoms in epileptic patients need to be determined before surgical procedures. Rigorous preoperative and postoperative evaluation is essential for psychiatry conditions in patients with refractory epilepsy candidates for surgery.
Dev Neurosci

中文翻译：

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颞叶癫痫手术患者左半球癫痫病灶偏侧化可能更常见

颞叶癫痫 (TLE) 被认为是最常见的癫痫形式，并且已经看到大多数患者对抗癫痫药物耐药。这种疾病与精神合并症，主要是情绪和焦虑障碍密切相关。癫痫的一侧可能会导致抑郁和焦虑症状；因此，在本研究中，我们进行了系统评价，以评估手术患者 TLE 中抑郁症的患病率。使用 PubMed/Medline、Web of Science 和 PsycNet 进行文献搜索，以收集从开始到 2019 年 1 月的数据。搜索策略与 TLE、抑郁症和焦虑症有关。阅读全文后，筛选出14篇符合纳入标准的文章。用于精神科诊断的主要方法是精神障碍诊断和统计手册/DSM结构化临床访谈。然而，大多数研究未能进行神经心理学评估。对于癫痫偏侧化者，病灶多发生在左半球。对于个体抑郁诊断，评估了 9 项研究，评估了 5 项研究。因此，从这两种情况下分析的数据来看，在术前和术后病例中没有代表性的诊断。为了估计手术在精神病发作中的疗效及其与癫痫发作控制的关系，需要在手术前确定癫痫患者出现抑郁和焦虑症状的风险。
开发神经科学