Importance and objectives

There is unmet medical need to understand the pathogenic mechanism of the panoply of clinical manifestations associated with silicone breast implants (SBIs) such as severe fatigue, widespread pain, palpitations, dry mouth and eyes, depression, hearing loss etc. We aimed to determine whether autoantibodies against the autonomic nervous system receptors can explain the enigmatic and subjective clinical manifestation reported by women with SBIs.

Results

Circulating level of autoantibodies against G protein-coupled receptors (GPCRs) of the autonomic nervous system (adrenergic, muscarinic, endothelin and angiotensin receptors) have been evaluated in symptomatic women with SBIs using an ELISA method. These women with SBIs addressed our clinic due to various subjective and autonomic-related manifestations such as chronic severe fatigue, cognitive impairment, widespread pain, memory loss, sleep disorders, palpitations, depression, hearing abnormalities etc. We report for the first time, a significant reduction in the sera level of anti-β1 adrenergic receptor (p < 0.001), anti-angiotensin II type 1 receptor (p < 0.001) and anti-endothelin receptor type A (p = 0.001) autoantibodies in women with SBIs (n = 93) as compared with aged matched healthy women (n = 36). Importantly, anti-β1 adrenergic receptor autoantibody was found to significantly correlate with autonomic-related manifestations such as: sleep disorders and depression in women with SBIs.

Conclusions

Chronic immune stimulation by silicone material may lead to an autoimmune dysautonomia in a subgroup of potentially genetically susceptible women with SBIs. The appearance of autoantibodies against GPCRs of the autonomic nervous system serve as an explanation for the subjective autonomic-related manifestations reported in women with SBIs.

中文翻译：

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硅胶乳房植入物女性的自身免疫性自主神经异常

重要性和目标

了解与硅胶乳房植入物 (SBI) 相关的一系列临床表现（如严重疲劳、广泛疼痛、心悸、口干和眼睛干燥、抑郁、听力丧失等）的发病机制尚未得到满足。我们旨在确定是否针对自主神经系统受体的自身抗体可以解释 SBI 女性报告的神秘而主观的临床表现。

结果

已经使用 ELISA 方法在有症状的 SBI 女性中评估了针对自主神经系统 G 蛋白偶联受体 (GPCR)（肾上腺素能、毒蕈碱、内皮素和血管紧张素受体）的自身抗体的循环水平。这些患有 SBI 的女性因各种主观和自主神经相关的表现（如慢性严重疲劳、认知障碍、广泛疼痛、记忆力减退、睡眠障碍、心悸、抑郁、听力异常等）来到我们的诊所。我们第一次报告， SBI 女性（n = 93）与年龄匹配的健康女性（n = 36）相比。重要的，

结论

有机硅材料的慢性免疫刺激可能导致具有 SBI 的潜在遗传易感女性亚组中的自身免疫性自主神经功能障碍。针对自主神经系统 GPCR 的自身抗体的出现可解释 SBI 女性报告的主观自主神经相关表现。