Preclinical research is a vital step in the drug discovery pipeline and more generally in helping to better understand human disease aetiology and its management. Systematic reviews (SRs) can be powerful in summarising and appraising this evidence concerning a specific research question, to highlight areas of improvements, areas for further research and areas where evidence may be sufficient to take forward to other research domains, for instance clinical trial. Guidance and tools for preclinical research synthesis remain limited despite their clear utility. We aimed to create an online end-to-end platform primarily for conducting SRs of preclinical studies, that was flexible enough to support a wide variety of experimental designs, was adaptable to different research questions, would allow users to adopt emerging automated tools and support them during their review process using best practice. In this article, we introduce the Systematic Review Facility (), which was launched in 2016 and designed to support primarily preclinical SRs from small independent projects to large, crowdsourced projects. We discuss the architecture of the app and its features, including the opportunity to collaborate easily, to efficiently manage projects, to screen and annotate studies for important features (metadata), to extract outcome data into a secure database, and tailor these steps to each project. We introduce how we are working to leverage the use of automation tools and allow the integration of these services to accelerate and automate steps in the systematic review workflow. No data are available. There are no data in this work.

中文翻译：

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在线系统审查平台的开发和采用：CAMARADES 系统审查设施 (SyRF) 的早年


临床前研究是药物发现流程中的重要一步，更广泛地说，有助于更好地了解人类疾病的病因学及其管理。系统评价（SR）可以有效地总结和评估有关特定研究问题的证据，以突出改进的领域、进一步研究的领域以及证据可能足以推进其他研究领域（例如临床试验）的领域。尽管临床前研究合成的指导和工具具有明显的实用性，但它们仍然有限。我们的目标是创建一个在线端到端平台，主要用于进行临床前研究的 SR，该平台足够灵活，可以支持各种实验设计，能够适应不同的研究问题，允许用户采用新兴的自动化工具和支持他们在审查过程中使用最佳实践。在本文中，我们介绍了系统审查工具 (Systematic Review Facility)，该工具于 2016 年启动，旨在主要支持从小型独立项目到大型众包项目的临床前 SR。我们讨论应用程序的架构及其功能，包括轻松协作的机会、高效管理项目、筛选和注释重要功能（元数据）的研究、将结果数据提取到安全数据库中，以及针对每个应用程序定制这些步骤项目。我们介绍了我们如何利用自动化工具并集成这些服务来加速和自动化系统审核工作流程中的步骤。无可用数据。这项工作中没有任何数据。