Worldwide, head and neck carcinomas account for 5% of all malignancies. Two-thirds of patients relapse after initial multimodal therapy. Until early 2010, the median overall survival (OS) of metastatic patients was about 10 months.

中文翻译：

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头颈部转移性鳞状细胞癌的全身治疗：管理变革建议。

在世界范围内，头颈癌占所有恶性肿瘤的 5%。三分之二的患者在初始多模式治疗后复发。直到 2010 年初，转移患者的中位总生存期 (OS) 约为 10 个月。