Schizophrenia is considered one of the most disabling and severe human diseases worldwide. The etiology of schizophrenia is thought to be multifactorial and evidence suggests that DNA methylation can play an important role in underlying pivotal neurobiological alterations of this disorder. Some studies have demonstrated the effects of dietary supplementation as an alternative approach to the prevention of schizophrenia, including folic acid. However, no study has ever investigated the role of such supplementation in altering the DNA methylation system in the context of schizophrenia.

中文翻译：

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母体叶酸补充对精神分裂症动物模型成年大鼠核甲基转移酶活性的影响

精神分裂症被认为是全世界最致残和最严重的人类疾病之一。精神分裂症的病因被认为是多因素的，有证据表明 DNA 甲基化可以在这种疾病的潜在关键神经生物学改变中发挥重要作用。一些研究已经证明了膳食补充剂作为预防精神分裂症的替代方法的效果，包括叶酸。然而，没有研究调查过这种补充剂在精神分裂症背景下改变 DNA 甲基化系统的作用。