Maternal nutrition affects offspring physiology and behavior including susceptibility to mental health-related states. Perinatal high-fat diet (HFD) consumption has been associated with lower levels of serotonin as well as the development of anxiety-like and depression-like behaviors in offspring. The aim of this systematic review was to investigate the effects of maternal HFD during pregnancy and/or lactation on these behaviors and on some aspects of the serotonergic system. Criteria for eligibility included studies of offspring of rodents and non-human primates exposed to HFD at least during pregnancy and/or lactation, offspring that showed outcomes related to anxiety-like and depression-like behaviors and to the serotonergic system. The searches were realized in the LILACS, Web of Science, Scopus, and PubMed databases. The systematic review protocol was registered on the CAMARADES website. The internal validity was assessed by the SYRCLE risk of bias tool. The Kappa index was used for analyzing agreement among the reviewers. In addition, the PRISMA statement was used to report this systematic review. Sixteen articles were included in this review. Most of which studied HFD prior to mating and during pregnancy and lactation. All studies analyzed outcomes related to emotional behavior; three analyzed outcomes related to serotonin system compounds. Maternal consumption of HFD was found to be associated with an inconsistent pattern of the expression of TPH2 as well as reduced the immunoreactivity of 5-HT in the prefrontal cortex and increased 5-HT1A receptor expression in the dorsal raphe of offspring. An association between an HFD and alterations in emotional behavior was found in most of the studies selected.

中文翻译：

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母亲暴露于高脂肪饮食会改变后代的焦虑样/抑郁样行为和血清素系统化合物：临床前系统评价

系统评价方案已在 CAMRADES 网站上注册。内部效度由 SYRCLE 偏倚风险工具评估。Kappa 指数用于分析评论者之间的一致性。此外，PRISMA 声明用于报告此系统评价。本综述纳入了 16 篇文章。其中大部分在交配前以及怀孕和哺乳期间研究了 HFD。所有研究都分析了与情绪行为相关的结果；三个与血清素系统化合物相关的分析结果。研究发现，母体食用 HFD 与 TPH2 表达的不一致模式以及降低前额叶皮层 5-HT 的免疫反应性和增加后代中缝背中 5-HT1A 受体的表达有关。