Coronary artery ectasia (CAE) is described as the enlargement of a coronary artery segment by 1.5 times or more, which is generally associated with the atherosclerotic process. Atherosclerotic changes lead to arterial remodeling result in CAE. In our study, we measured serum transforming growth factor (TGF)-β1 levels, which have a protective role against atherosclerosis. Further, we aimed to assess the TGF-β1 gene variants rs1800469 (–509C>T, c.−1347C>T) and rs1800470 (c.+29T>C, p.Pro10Leu, rs1982073), which might have an effect on TGF production. Overall, 2877 patients were screened including 56 patients with CAE and 44 patients with normal coronary arteries who were included in the study. Serum TGF-β1 levels were measured using ELISA and compared between two groups. Additionally, TGF-β1 rs1800469 and rs1800470 gene variations were determined using TaqMan® SNP Genotyping Assays. Serum TGF-β1 levels were significantly lower in patients with CAE than in controls (p=0.012). However, there was no difference in terms of the genotype and allele distributions of TGF-β1 rs1800469 and rs1800470 polymorphisms. Serum TGF-β1 levels were higher in individuals carrying the TGF-β1 rs1800470 G allele (GG+AG) than in individuals with normal homozygous AA genotype in the CAE group (p=0.012). Our findings suggest that lower serum TGF-β1 levels are associated with an increased risk for CAE development and that TGF-β1 polymorphisms exert a protective effect. Furthermore, TGF-β1 rs1800470 G allele carriers were shown to have higher TGF-β1 levels in the CAE group. This suggests that having the G allele in the TGF-β1 rs1800470 polymorphism could prevent CAE development.

中文翻译：

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冠状动脉扩张症和正常冠状动脉患者血清TGF-β水平及相关多态性的比较

冠状动脉扩张（CAE）被描述为冠状动脉节段增大1.5倍或更多，这通常与动脉粥样硬化过程有关。动脉粥样硬化的变化导致CAE的动脉重塑。在我们的研究中，我们测量了血清转化生长因子（TGF）-β1的水平，该水平对动脉粥样硬化具有保护作用。此外，我们旨在评估可能对TGF有影响的TGF-β1基因变体rs1800469（–509C> T，c.-1347C> T）和rs1800470（c。+ 29T> C，p.Pro10Leu，rs1982073）。生产。总共筛选了2877例患者，其中包括56例CAE患者和44例冠状动脉正常的患者。使用ELISA测量血清TGF-β1水平，并在两组之间进行比较。此外，TGF-β1rs1800469和rs1800470基因变异是使用TaqMan®SNP基因分型测定法确定的。CAE患者的血清TGF-β1水平显着低于对照组（p = 0.012）。但是，TGF-β1rs1800469和rs1800470多态性的基因型和等位基因分布没有差异。在CAE组中，携带TGF-β1rs1800470 G等位基因（GG + AG）的个体的血清TGF-β1水平高于具有纯合AA基因型的个体（p = 0.012）。我们的发现表明，较低的血清TGF-β1水平与CAE发生的风险增加有关，并且TGF-β1多态性发挥了保护作用。此外，在CAE组中，TGF-β1rs1800470 G等位基因携带者显示出较高的TGF-β1水平。