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Effect of quantitative values on shortened acquisition duration in brain tumor 11C-methionine PET/CT
EJNMMI Physics ( IF 3.0 ) Pub Date : 2021-03-31 , DOI: 10.1186/s40658-021-00379-2
Masatoshi Morimoto , Nobuyuki Kudomi , Yukito Maeda , Takuya Kobata , Akihiro Oishi , Keisuke Matsumoto , Toshihide Monden , Takanobu Iwasaki , Katsuya Mitamura , Takashi Norikane , Yuka Yamamoto , Yoshihiro Nishiyama

The amount of signal decreases when the acquisition duration is shortened. However, it is not clear how this affects the quantitative values. This study aims to clarify the effect of acquisition time shortening in brain tumor PET/CT using 11C-methionine on the quantitative values. This study was a retrospective analysis of 30 patients who underwent clinical 11C-methionine PET/CT examination. PET images were acquired in list mode for 10 min. PET images of acquisition duration from 1 to 10 min with 1-min step were reconstructed. We examined the effect on the quantitative values of acquisition duration. We placed a volume of interest to include the entire tumor and regions of interest in the shape of a large crescent in the contralateral hemisphere in 5 contiguous axial slices as normal tissue. Quantitative values examined were maximum, peak, and mean standardized uptake values (SUVmax, SUVpeak, SUVmean), metabolic tumor volume (MTV), and maximum tumor to normal tissue ratio (TNRmax), with each duration compared to that with 10 min. SUVmax, MTV, and TNRmax showed the highest values due to the effects of statistical noise when the acquisition time was 1 min. These values were stable when the acquisition duration was > 6 min. SUVpeak and SUVmean showed mostly consistent values regardless of duration. SUVmax, MTV, and TNRmax are affected by acquisition time. If the acquisition duration was > 6 min, the fluctuation could be suppressed within 5% in these quantitative values. However, SUVpeak was suggested to be a robust index regardless of the acquisition duration.

中文翻译:

定量值对缩短脑肿瘤11 C-蛋氨酸PET / CT采集时间的影响

当采集持续时间缩短时,信号量会减少。但是,尚不清楚这如何影响定量值。这项研究旨在阐明使用11 C-蛋氨酸在脑肿瘤PET / CT中缩短采集时间对定量值的影响。这项研究是对30例接受11C-蛋氨酸PET / CT临床检查的患者的回顾性分析。以列表模式采集PET图像10分钟。以1分钟为步长重建1到10分钟的采集持续时间的PET图像。我们检查了对采集持续时间定量值的影响。我们放置了一个感兴趣的体积,以对侧半球的五个新月形轴向切片中的正常组织形式包括整个肿瘤和感兴趣的区域(呈新月形)。检查的定量值为最大值,峰值,平均持续摄取时间(SUVmax,SUVpeak,SUVmean),代谢肿瘤体积(MTV)和最大肿瘤与正常组织之比(TNRmax),每次持续时间与10分钟相比。当采集时间为1分钟时,由于统计噪声的影响,SUVmax,MTV和TNRmax显示出最大值。当采集持续时间> 6分钟时,这些值是稳定的。无论持续时间如何,SUVpeak和SUVmean都显示出基本一致的值。SUVmax,MTV和TNRmax受采集时间的影响。如果采集持续时间> 6分钟,则这些定量值的波动可抑制在5%以内。但是,无论采集持续时间如何,建议SUVpeak都是可靠的指标。每次持续时间与10分钟相比,最大肿瘤与正常组织之比(TNRmax)。当采集时间为1分钟时,由于统计噪声的影响,SUVmax,MTV和TNRmax显示出最大值。当采集持续时间> 6分钟时,这些值是稳定的。无论持续时间如何,SUVpeak和SUVmean都显示出基本一致的值。SUVmax,MTV和TNRmax受采集时间的影响。如果采集持续时间> 6分钟,则这些定量值的波动可抑制在5%以内。但是,无论采集持续时间如何,建议SUVpeak都是可靠的指标。每次持续时间与10分钟相比,最大肿瘤与正常组织之比(TNRmax)。当采集时间为1分钟时,由于统计噪声的影响,SUVmax,MTV和TNRmax显示出最大值。当采集持续时间> 6分钟时,这些值是稳定的。无论持续时间如何,SUVpeak和SUVmean都显示出基本一致的值。SUVmax,MTV和TNRmax受采集时间的影响。如果采集持续时间> 6分钟,则这些定量值的波动可抑制在5%以内。但是,无论采集持续时间如何,建议SUVpeak都是可靠的指标。当采集持续时间> 6分钟时,这些值是稳定的。无论持续时间如何,SUVpeak和SUVmean都显示出基本一致的值。SUVmax,MTV和TNRmax受采集时间的影响。如果采集持续时间> 6分钟,则这些定量值的波动可抑制在5%以内。但是,无论采集持续时间如何,建议SUVpeak都是可靠的指标。当采集持续时间> 6分钟时,这些值是稳定的。无论持续时间如何,SUVpeak和SUVmean都显示出基本一致的值。SUVmax,MTV和TNRmax受采集时间的影响。如果采集持续时间> 6分钟,则这些定量值的波动可抑制在5%以内。但是,无论采集持续时间如何,建议SUVpeak都是可靠的指标。
更新日期:2021-03-31
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