The autoantibody profile of primary biliary cholangitis (PBC) includes antinuclear antibodies (ANA) which are detectable by indirect immunofluorescence in more than 50% of PBC patients. One of the two immunofluorescence patterns which are historically considered “PBC-specific” is the so-called “multiple nuclear dots” (MND) targeting nuclear body proteins such as Sp100, Sp140, Sp140L proteins, promyelocytic leukemia protein (PML) and small ubiquitin-related modifier proteins (SUMO). It has been hypothesized a role of nuclear body protein alterations in immune disorders such as PBC, thus suggesting novel and more refined therapeutic approaches.

中文翻译：

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原发性胆源性胆管炎中斑点蛋白家族的自身抗体

原发性胆源性胆管炎（PBC）的自身抗体谱包括抗核抗体（ANA），可通过间接免疫荧光检测在50％以上的PBC患者中进行检测。历史上被认为是“ PBC特异性”的两种免疫荧光模式之一是针对核蛋白（例如Sp100，Sp140，Sp140L蛋白，早幼粒细胞白血病蛋白（PML）和泛素小蛋白）的“多核点”（MND）相关的修饰蛋白（SUMO）。已经假设核体蛋白改变在免疫疾病例如PBC中的作用，因此提示了新颖且更完善的治疗方法。