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Nanoemulsions: The rising star of antiviral therapeutics and nanodelivery system—current status and prospects
Current Opinion in Colloid & Interface Science ( IF 7.9 ) Pub Date : 2021-03-30 , DOI: 10.1016/j.cocis.2021.101458
Jonathan Sampath Franklyne 1 , Ponnusamy Manogaran Gopinath 1 , Amitava Mukherjee 1 , Natarajan Chandrasekaran 1
Affiliation  

Nanoemulsions (NEs) of essential oil (EO) have significant potential to target microorganisms, especially viruses. They act as a vehicle for delivering antiviral drugs and vaccines. Narrowing of drug discovery pipeline and the emergence of new viral diseases, especially, coronavirus disease, have created a niche to use NEs for augmenting currently available therapeutic options. Published literature demonstrated that EOs have an inherent broad spectrum of activity across bacterial, fungal, and viral pathogens. The emulsification process significantly improved the efficacy of the active ingredients in the EOs. This article highlights the research findings and patent developments in the last 2 years especially, in EO antiviral activity, antiviral drug delivery, vaccine delivery, viral resistance development, and repurposing EO compounds against SARS-CoV-2.



中文翻译:

纳米乳剂:抗病毒治疗和纳米递送系统的后起之秀——现状与展望

精油 (EO) 的纳米乳液 (NEs) 具有针对微生物,尤其是病毒的巨大潜力。它们充当提供抗病毒药物和疫苗的载体。药物发现管道的缩小和新病毒性疾病(尤其是冠状病毒病)的出现,为使用 NEs 增加当前可用的治疗选择创造了一个利基市场。已发表的文献表明,EO 对细菌、真菌和病毒病原体具有固有的广谱活性。乳化过程显着提高了 EO 中活性成分的功效。本文重点介绍了过去 2 年的研究成果和专利进展,尤其是在 EO 抗病毒活性、抗病毒药物递送、疫苗递送、病毒耐药性发展、

更新日期:2021-04-27
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