The incorporation of drugs and bioactive compounds in the natural rubber latex (NRL) matrix has been an alternative for the development of transdermal release membranes. Ibuprofen (IBF) is known to be used to treat inflammatory diseases, but when administered orally, high concentrations can cause some adverse problems. In this work, the incorporation of IBF in the NRL membranes was evaluated by physical-chemical, in vitro permeation, hemocompatibility and molecular modeling assays. In addition, the in vitro release profile of IBF in acid and basic media was analyzed during 96 h. The IBF-NRL membrane exhibited the absence of intermolecular bonding that could hinder drug release and presented compatible mechanical properties for applications as a cutaneous adhesive (0.58 and 1.12 MPa to Young’s modulus and rupture tension, respectively). The IBF-NRL system did not present a significant hemolysis degree (1.67%) within 24 h. The release test indicated that in the first hours of the study, 48.5% IBF was released at basic pH and 22.5% at acidic pH, which is characteristic of a burst effect. Then, a stable release profile was observed until the end of the assay, with total IBF release of 60% in alkaline medium and 50% in acidic medium. The drug permeation results indicated that the IBF-NRL membranes can be used for the local skin treatment with permeation of 3.11% of IBF. Dynamic Molecular simulations indicated a pronounced electric dipole in the ionized form of IBF, which suggests a more effective interaction with water, explaining the efficient drug release in alkaline solutions. In general, the results demonstrate that the IBF-NRL membrane has great potential for a new adhesive that can be used for the treatment of inflammatory processes and injuries.

在天然橡胶胶乳 (NRL) 基质中加入药物和生物活性化合物已成为开发透皮释放膜的替代方案。已知布洛芬 (IBF) 可用于治疗炎症性疾病，但当口服给药时，高浓度会导致一些不良问题。在这项工作中，IBF 在 NRL 膜中的掺入通过物理化学、体外渗透、血液相容性和分子建模分析进行了评估。此外，体外在 96 小时内分析了 IBF 在酸性和碱性介质中的释放曲线。IBF-NRL 膜表现出不存在可能阻碍药物释放的分子间键合，并呈现出适合作为皮肤粘合剂应用的兼容机械性能（杨氏模量和断裂张力分别为 0.58 和 1.12 MPa）。IBF-NRL 系统在 24 小时内没有出现显着的溶血程度（1.67%）。释放测试表明，在研究的前几个小时，碱性 pH 值下释放了 48.5% 的 IBF，酸性 pH 值下释放了 22.5%，这是爆发效应的特征。然后，观察到稳定的释放曲线直到试验结束，总 IBF 释放在碱性介质中为 60%，在酸性介质中为 50%。药物渗透结果表明IBF-NRL膜可用于局部皮肤治疗，渗透率为3.11%。动态分子模拟表明 IBF 的电离形式具有明显的电偶极子，这表明与水的相互作用更有效，解释了在碱性溶液中药物的有效释放。总的来说，结果表明 IBF-NRL 膜具有巨大的潜力，可用于治疗炎症过程和损伤的新型粘合剂。