Several clinic-based and large population studies have associated a depression diagnosis or depression severity with dry eye disease (DED) or symptoms. On the other hand, several other large population studies have found that antidepressant use was also associated with DED. Unfortunately, many of the studies finding associations between depression and DED did not control for concomitant antidepressant use, whereas the ones that found associations between antidepressant use and DED did not control for severity of depression or other psychiatric indications for selective serotonin inhibitor use. The purpose of this review was to identify whether depression and antidepressants play an independent role from one another in the onset of DED.

中文翻译：

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擦干那些哭泣的眼睛：抑郁症和抗抑郁药在干眼症中的作用。

几项基于临床的大型人群研究已将抑郁症诊断或抑郁症严重程度与干眼病 (DED) 或症状联系起来。另一方面，其他几项大型人群研究发现，抗抑郁药的使用也与 DED 相关。不幸的是，许多发现抑郁症与 DED 之间关联的研究并未控制同时使用抗抑郁药，而发现抗抑郁药使用与 DED 之间关联的研究并未控制抑郁症的严重程度或选择性使用血清素抑制剂的其他精神病学适应症。本综述的目的是确定抑郁症和抗抑郁药是否在 DED 发作中相互独立。