Covalent organic nanospheres are new kind of nanospherical polymer with large specific surface area, uniform morphology, and excellent chemical and thermal stability. This material can be fabricated by a facile and rapid room temperature solution-phase strategy. In this work, magnetic nanoparticles were attached to the surface of covalent organic nanospheres, and the obtained composites were used for the extraction of blood lipid regulators such as clofibrate and fenofibrate. These composites were characterized with Fourier-transformed infrared spectroscopy, X-ray photoelectron spectroscopy, and transmission electron microscopy. Several parameters that might affect the extraction efficiency including acetonitrile content, pH value, extraction time, and sample volume were investigated. Under optimum conditions, the proposed analytical method showed high extraction efficiency toward clofibrate and fenofibrate with enrichment factors between 60 and 83. This method exhibited outstanding analytical performance with wide linear range and excellent reproducibility and had low limits of detection in the range of 0.02–0.03 ng/mL. This method was also applied to the detection of clofibrate and fenofibrate in lake water samples, and good recoveries in the range of 92.6–112.6% was obtained.

中文翻译：

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共价有机纳米球修饰磁性纳米粒子用于提取水样中的血脂调节剂

共价有机纳米球是一种比表面积大、形貌均匀、化学和热稳定性优良的新型纳米球形聚合物。这种材料可以通过简单快速的室温溶液相策略制造。在这项工作中，磁性纳米粒子附着在共价有机纳米球的表面，所得复合物用于提取血脂调节剂，如氯贝特和非诺贝特。这些复合材料用傅里叶变换红外光谱、X 射线光电子能谱和透射电子显微镜进行了表征。研究了可能影响萃取效率的几个参数，包括乙腈含量、pH 值、萃取时间和样品体积。在最佳条件下，所提出的分析方法对氯贝特和非诺贝特的提取效率高，富集因子在 60 到 83 之间。该方法具有出色的分析性能，线性范围宽，重现性好，检测限低，范围为 0.02-0.03 ng/mL。该方法还用于检测湖水样品中的氯贝特和非诺贝特，回收率在 92.6-112.6% 之间。