The study by Li et al., provides a detailed pharmacological characterization of the ionic mechanisms that underlie rhythmic activity of retrotrapezoid nucleus neurons that control breathing. Specifically, the authors demonstrate a role of the transient receptor potential melastatin 4 (TRPM4) ion channel in the generation of subthreshold excitatory oscillations. Additionally, they propose that the ion channel contributes to tonic action potential (AP) firing – referred to as “pacemaking” – of these brainstem neurons with relevance for respiratory breathing and homeostasis in vivo.

中文翻译：

---

TRPM4 跟上步伐

Li 等人的研究提供了离子机制的详细药理学表征，这些离子机制是控制呼吸的后梯形核神经元节律活动的基础。具体来说，作者证明了瞬态受体电位 melastatin 4 (TRPM4) 离子通道在阈下兴奋性振荡的产生中的作用。此外，他们还提出，所述离子通道有助于补药动作电位（AP）发射-称为“起搏” -这些脑干神经元与相关性，为呼吸呼吸和内环境稳定的体内。