Cellular senescence is the irreversible cell cycle arrest in response to DNA damage. Because senescent cells accumulate with age and contribute to chronic inflammation, they are promising therapeutic targets for healthspan extension. The senescent phenotype can vary depending on cell type and on the specific insults that induce senescence. This variability is also reflected in the extensive remodeling of the genome organization within the nucleus of senescent cells. Here, we give an overview of the nuclear changes that occur in different forms of senescence, including changes to chromatin state and composition and to the three-dimensional organization of the genome, as well as alterations to the nuclear envelope and to the accessibility of repetitive genomic regions. Many of these changes are shared across all forms of senescence, implicating nuclear organization as a fundamental driver of the senescent state and of how senescent cells interact with the surrounding tissue.

中文翻译：

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核重组对细胞衰老的功能影响

细胞衰老是响应 DNA 损伤的不可逆细胞周期停滞。由于衰老细胞随着年龄的增长而积累并导致慢性炎症，因此它们是延长健康寿命的有希望的治疗目标。衰老表型可以根据细胞类型和诱导衰老的特定损伤而变化。这种变异性也反映在衰老细胞核内基因组组织的广泛重塑中。在这里，我们概述了不同衰老形式中发生的核变化，包括染色质状态和组成的变化以及基因组三维组织的变化，以及核包膜的改变和重复的可及性。基因组区域。许多这些变化在所有形式的衰老中都有所共有，