Coronary artery diseases are the major causes of disabilities and death worldwide. Evidence from the literature has demonstrated that Origanum majorana L. (marjoram) acts as an antioxidant, anti-inflammatory, antiplatelet, and assists in hormonal regulation. However, there is limited scientific evidence describing the signaling pathways associated with the marjoram’s positive effect on cardiac injury. Therefore, we aimed to understand the mechanistic protective effects of marjoram on isoproterenol (ISO)-induced myocardial injury in rats. Sprague Dawley rats were randomly assigned into six groups. Marjoram was administrated by oral gavage and isoproterenol was administrated subcutaneously (ISO; 85 mg/kg). Heart weight, cardiac enzymes, inflammatory, and oxidative stress biomarkers were measured. The ISO-induced cardiac injury was confirmed by the significant increase in the levels of cardiac enzymes (P value < 0.05), whereas pre-treatment with marjoram normalized these cardiac injury parameters. We also determined that marjoram had a protective effect against ISO-induced increase in C-reactive protein (CRP), IL-6, IL-13, and TNF-α. Additionally, marjoram significantly decreased cardiac thiobarbituric acid reactive substances (TBARS) levels (P value < 0.05) and protected against ISO-induced oxidative stress. We have demonstrated that marjoram decreased both cardiac oxidative stress and inflammation, thus establishing the beneficial effects of marjoram on ISO-induced cardiac injury in rats.

冠状动脉疾病是全世界残疾和死亡的主要原因。文献证据表明，牛至（牛至兰）具有抗氧化、抗炎、抗血小板作用，并有助于激素调节。然而，描述与马郁兰对心脏损伤的积极作用相关的信号传导途径的科学证据有限。因此，我们的目的是了解马郁兰对异丙肾上腺素（ISO）诱导的大鼠心肌损伤的机制保护作用。 Sprague Dawley 大鼠被随机分为六组。通过口服强饲法施用马郁兰，并皮下施用异丙肾上腺素（ISO；85mg/kg）。测量心脏重量、心肌酶、炎症和氧化应激生物标志物。 ISO 诱导的心脏损伤通过心肌酶水平的显着增加得到证实（ P值 < 0.05），而马郁兰预处理使这些心脏损伤参数正常化。我们还确定马郁兰对 ISO 诱导的 C 反应蛋白 (CRP)、IL-6、IL-13 和 TNF-α 增加具有保护作用。此外，马郁兰可显着降低心脏硫代巴比妥酸反应物质 (TBARS) 水平（ P值 < 0.05），并防止 ISO 诱导的氧化应激。我们已经证明马郁兰可减少心脏氧化应激和炎症，从而确定马郁兰对 ISO 诱导的大鼠心脏损伤具有有益作用。