Abstract

Sesquiterpenoids have been identified as natural compounds showing remarkable biological activities found in medicinal plants. There is great interest in developing methods to obtain sesquiterpenoids derivatives and biotransformation is one of the alternative methods for structural modification of complex sesquiterpenes structures. Biotransformation is a great drug design tool offering high selectivity and green method. The present review describes a comprehensive summary of biotransformation products of sesquiterpenoids and its structural modification utilizing a variety of biocatalysts including microorganisms, plant tissue culture and enzymes. This review covers recent literatures from 2007 until 2020 and highlights the experimental conditions for each biotransformation process.

摘要

倍半萜类化合物已被鉴定为在药用植物中发现的具有显着生物活性的天然化合物。人们对开发获得倍半萜类衍生物的方法非常感兴趣，而生物转化是对复杂倍半萜结构进行结构修饰的替代方法之一。生物转化是一种很好的药物设计工具，提供了高选择性和绿色方法。本综述全面总结了倍半萜类化合物的生物转化产物及其利用各种生物催化剂（包括微生物、植物组织培养物和酶）进行的结构修饰。这篇综述涵盖了从 2007 年到 2020 年的最新文献，并强调了每个生物转化过程的实验条件。