ABSTRACT

Biodistribution and tumour agglomeration of chemotherapeutic drugs are improved by nanoparticles augmenting the ratio of efficacy and toxicity. Iron oxide nanoparticles have attracted growing attention in diagnosis, cancer therapy, and smart drug delivery. To simplify the combined therapy and targeting drug delivery such as using ultrasound, we developed magnetoliposome-encapsulated doxorubicin. Superparamagnetic iron oxide nanoparticles and magnetoliposome-encapsulated doxorubicin were well synthesised without any remarkable mitigation of the saturation magnetisation. Doxorubicin and the synthesised iron oxide nanoparticles were passively encapsulated into PEGylated liposomes leading to stable soluble magnetoliposomes with a size of about 485 nm. The cytotoxicity of doxorubicin-loaded magnetoliposomes was examined on MCF-7 cells. Compared with chemotherapy alone, the combined therapy employing ultrasound showed a synergistic effect, giving rise to more robust cytotoxicity and higher therapeutic efficacy. Hence, the multifunctional doxorubicin-loaded magnetoliposomes permit them to selectively deliver a combinatorial therapeutic load with increased therapeutic effectiveness.

摘要

通过增加疗效和毒性比率的纳米颗粒来改善化疗药物的生物分布和肿瘤聚集。氧化铁纳米颗粒在诊断、癌症治疗和智能药物输送方面引起了越来越多的关注。为了简化联合治疗和靶向药物递送（例如使用超声），我们开发了磁脂质体包裹的阿霉素。超顺磁性氧化铁纳米颗粒和磁脂质体包裹的阿霉素被很好地合成，而没有显着减轻饱和磁化强度。多柔比星和合成的氧化铁纳米颗粒被被动封装到聚乙二醇化脂质体中，从而形成尺寸约为 485 nm 的稳定可溶性磁性脂质体。在 MCF-7 细胞上检测了负载多柔比星的磁性脂质体的细胞毒性。与单纯化疗相比，超声联合治疗显示出协同作用，产生更强的细胞毒性和更高的治疗效果。因此，多功能多柔比星负载磁脂质体允许它们选择性地递送组合治疗负荷，并提高治疗效果。