Abstract

Recent initiatives covered in this review can be divided into three broad categories. The first category concerns mathematically describing the spray drying process using a plug-flow model which allows quick what-if evaluations of the process. Intricacies associated with capturing the drying of a range of droplet sizes are discussed. Challenges in adapting the plug-flow simulation approach to counter-current spray drying, which is common in the production of non-heat sensitive detergent powder, was further elaborated. The second broad category features modeling the spray drying process using the Computational Fluid Dynamics technique. A critical review was provided to guide readers on a common dilemma plaguing this area of spray drying modeling. Recent developments in agglomeration modeling in spray dryers are discussed as well. The final part of this review touches on modeling techniques which can be used to predict the development of specific powder qualities. This includes modeling the degree of protein denaturation during spray drying, predicting the characteristics of crystalline type spray dried powder, and determining the properties of the powder surface at the molecular scale.

摘要

本次审查涵盖的近期举措可分为三大类。第一类涉及使用推流模型以数学方式描述喷雾干燥过程，该模型允许对过程进行快速假设评估。讨论了与捕获一系列液滴尺寸的干燥相关的复杂性。进一步阐述了将活塞流模拟方法应用于逆流喷雾干燥的挑战，这在非热敏洗涤剂粉末的生产中很常见。第二大类的特点是使用计算流体动力学技术对喷雾干燥过程进行建模。提供了批判性评论，以指导读者解决困扰喷雾干燥建模领域的常见困境。还讨论了喷雾干燥器中团聚建模的最新进展。本评论的最后一部分涉及建模技术，可用于预测特定粉末质量的发展。这包括模拟喷雾干燥过程中的蛋白质变性程度，预测结晶型喷雾干燥粉末的特性，以及在分子尺度上确定粉末表面的特性。