In Fionda et al.,1 Figure 1 erroneously included only one part of the image. The correct and complete figure image is shown below.
FIGURE 1
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The p.(Asp361_Leu365del) deletion eliminates two of the calcium ligands in synaptotagmin-2 (SYT2) C2B domain and causes distal weakness and foot deformities. A, The patient needed surgery for correction of pes cavus and foot deformities during early childhood. However, no relevant lower limb distal wasting in anterolateral compartment at the age of 30. B, Hematoxylin and Eosin staining of the muscle biopsy of gastrocnemius muscle showed fiber size variability, internal nuclei, and mild changes suggestive of a neurogenic process such as scattered angulated fibers and nuclear clumps (Objective 20x). C, 3D model of the human SYT2 C2B domain (residues Glu269-Gly416, marked as N-t and C-t, respectively), shown as a forest green-colored cartoon, with beta-strands as arrows and alpha helices as ribbons. The side chains of aspartate and glutamate residues that coordinate Ca2+ ions -represented as light orange spheres- are shown with all their non-hydrogen atoms, color-coded (carbon, green; nitrogen, blue; oxygen, red). The side chain of residue Ile371 is also shown and labeled. A bound phosphoserine molecule (SEP) that marks the position of the vesicle membrane is also given color-coded (carbon, yellow; phosphor, orange)
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