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Synthesis, Photochemical Properties, and Cytotoxicity of 10-Alkylphenazin-2(10
Heterocycles ( IF 0.8 ) Pub Date : 2021-03-29 , DOI: 10.3987/com-21-14420
Kouji Kuramochi , Haruki Kohatsu , Takuya Hosokai , Kenji Ohgane , Shogo Kamo , Shinji Kamisuki , Yutaro Machida , Ryota Kobayashi , Tsuneomi Kawasaki

In the present study, the synthesis of a variety of 10-alkylphenazin-2(10H)-ones by oxidative coupling between N-alkylbenzene-1,2-diamine and 1,2,4-benzenetriol under an oxygen atmosphere was realized, and their photochemical and biological properties were investigated. 10-Methylphenazin-2(10H)-one, a reddish orange pigment, exhibited fluorescence in the visible light region upon exposure to ultraviolet light. Interestingly, the fluorescence from 10-methylphenazin-2(10H)-one consisted of two components. In addition, the cytotoxic evaluation of various synthetic compounds was performed. Among the compounds tested in this study, 10-methylphenazin-2(10H)-one exhibited the most selective cytotoxic activity against human cancer A549 cells compared to normal MRC-5 cells.

中文翻译:

10-烷基吩嗪-2(10的合成,光化学性质和细胞毒性

在本研究中,通过在氧气气氛下N-烷基苯-1,2-二胺和1,2,4-苯三酚之间的氧化偶联,实现了多种10-烷基吩嗪-2(10 H )-的合成,并对其光化学和生物学特性进行了研究。10-Methylphenazin-2(10 H )-one,一种红橙色颜料,在暴露于紫外光后在可见光区域显示荧光。有趣的是,10-methylphenazin-2(10 H )-one发出的荧光由两个成分组成。另外,进行了各种合成化合物的细胞毒性评价。在这项研究中测试的化合物中,10-methylphenazin-2(10 H)-与正常MRC-5细胞相比,对人癌A549细胞表现出最具选择性的细胞毒活性。
更新日期:2021-05-27
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