In the present study, the synthesis of a variety of 10-alkylphenazin-2(10H)-ones by oxidative coupling between N-alkylbenzene-1,2-diamine and 1,2,4-benzenetriol under an oxygen atmosphere was realized, and their photochemical and biological properties were investigated. 10-Methylphenazin-2(10H)-one, a reddish orange pigment, exhibited fluorescence in the visible light region upon exposure to ultraviolet light. Interestingly, the fluorescence from 10-methylphenazin-2(10H)-one consisted of two components. In addition, the cytotoxic evaluation of various synthetic compounds was performed. Among the compounds tested in this study, 10-methylphenazin-2(10H)-one exhibited the most selective cytotoxic activity against human cancer A549 cells compared to normal MRC-5 cells.

中文翻译：

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10-烷基吩嗪-2（10的合成，光化学性质和细胞毒性

在本研究中，通过在氧气气氛下，N-烷基苯-1，2-二胺和1,2,4-苯三酚之间的氧化偶联，实现了多种10-烷基吩嗪-2（10 H ）-的合成，并对其光化学和生物学特性进行了研究。10-Methylphenazin-2（10 H ）-one，一种红橙色颜料，在暴露于紫外光后在可见光区域显示荧光。有趣的是，10-methylphenazin-2（10 H ）-one发出的荧光由两个成分组成。另外，进行了各种合成化合物的细胞毒性评价。在这项研究中测试的化合物中，10-methylphenazin-2（10 H）-与正常MRC-5细胞相比，对人癌A549细胞表现出最具选择性的细胞毒活性。