ABSTRACT

Introduction

Chronic kidney disease is avery common and complex chronic disease. Uncovering the pathological patterns of CKD on the molecular level of bio-fluids and tissue appears to be both vital and promising for a more favorable outcome. We reviewed recently discovered proteomics biomarkers for CKD to provide new insight into disease pathology.

Areas covered

We review the application of proteome analysis in the context of CKD with various etiologies within the last 5 years. Proteins and peptides associated with CKD as derived from multiple sources (urine, blood and tissue) are reported along with their various biological pathways.

Expert opinion

A systematic and theoretical comprehension of the CKD pathology is essential for its successful management. The underlying complexity of the disease further requires specific conditions for reliable and interpretable results. In this context, clinical proteomics has resulted in first encouraging findings in CKD. A more complete understanding of the biological pathways related to the disease, based on the scope of a holistic proteomic approach, could improve substantially the management of CKD, especially when in conjunction with the current trend of personalized medicine.

中文翻译：

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通过蛋白质组学了解肾小球疾病

摘要

介绍

慢性肾脏病是一种非常常见和复杂的慢性疾病。在生物体液和组织的分子水平上揭示 CKD 的病理模式对于获得更有利的结果似乎既重要又有希望。我们回顾了最近发现的 CKD 蛋白质组学生物标志物，以提供对疾病病理学的新见解。

涵盖的领域

我们回顾了过去 5 年内蛋白质组分析在具有各种病因的 CKD 中的应用。报道了来自多种来源（尿液、血液和组织）的与 CKD 相关的蛋白质和肽以及它们的各种生物学途径。

专家意见

对 CKD 病理学的系统性和理论性理解对于其成功管理至关重要。该疾病的潜在复杂性进一步需要特定条件才能获得可靠和可解释的结果。在这种情况下，临床蛋白质组学在 CKD 中取得了第一个令人鼓舞的发现。基于整体蛋白质组学方法的范围，更全面地了解与疾病相关的生物学途径，可以显着改善 CKD 的管理，尤其是在结合当前个性化医疗趋势时。