ABSTRACT

Background

Current study was to evaluate the association of hypertensive and hypertension phenotypes in hypertensive populations.

Methods

Patients with primary hypertension and without any uric acid (UA)-lowering treatment were enrolled. Baseline characteristics including office blood pressure (OBP), 24 h ambulatory blood pressure (ABP), and serum UA (SUA) were measured. According to SUA, patients were divided into normal SUA and hyperuricemia groups. Based on OBP and 24 h-ABP, hypertension phenotypes were classified as controlled hypertension (CH), white-coat uncontrolled hypertension (WCUH), masked uncontrolled hypertension (MUCH), and sustained uncontrolled hypertension (SUCH).

Results

Compared to patients with normal SUA (n = 336), patients with hyperuricemia (n = 284) were older and more likely to be men, obese, physically inactive, and have a higher prevalence of diabetes. C-reactive protein (CRP) level was higher in patients with hyperuricemia. The prevalence of CH, WCUH, and MUCH was similar between these two groups. However, the prevalence of SUCH was higher in patients with hyperuricemia than patients with normal SUA. Linear regression analysis indicated that increased SUA was significantly associated with 24 h-systolic BP and daytime-systolic BP. Normal SUA was served as the reference group, and presence of hyperuricemia was associated with higher odds of SUCH (odds ratio 1.46 and 95% confidence interval 1.27–1.93) after adjusted for potential covariates including age, male gender, obesity, diabetes, CRP, and antihypertensive drugs.

Conclusion

In hypertensive patients without UA-lowering treatment, presence of hyperuricemia was associated with higher odds of SUCH. Future studies are needed to evaluate whether lowering SUA can help to improve 24 h-ABP control.

中文翻译：

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未经降尿酸治疗的高血压患者高尿酸血症与高血压表型的相关性

摘要

背景

目前的研究旨在评估高血压人群中高血压和高血压表型的相关性。

方法

入组患有原发性高血压且未接受任何降尿酸 (UA) 治疗的患者。测量了包括诊室血压 (OBP)、24 小时动态血压 (ABP) 和血清尿酸 (SUA) 在内的基线特征。根据SUA，将患者分为正常SUA组和高尿酸血症组。基于 OBP 和 24 h-ABP，高血压表型分为控制性高血压 (CH)、白大衣未控制性高血压 (WCUH)、隐匿性未控制性高血压 (MUCH) 和持续性未控制性高血压 (SUCH)。

结果

与 SUA 正常的患者（n = 336）相比，高尿酸​​血症患者（n= 284) 年龄较大，更有可能是男性、肥胖、缺乏运动，并且糖尿病患病率较高。高尿酸血症患者的 C 反应蛋白 (CRP) 水平较高。这两组之间 CH、WCUH 和 MUCH 的患病率相似。然而，高尿酸血症患者的 SUCH 患病率高于正常 SUA 患者。线性回归分析表明，增加的 SUA 与 24 小时收缩压和白天收缩压显着相关。正常 SUA 被用作参考组，在调整潜在协变量（包括年龄、男性、肥胖、糖尿病、CRP、和抗高血压药物。

结论

在未进行 UA 降低治疗的高血压患者中，高尿酸血症的存在与 SUCH 的较高几率相关。需要未来的研究来评估降低 SUA 是否有助于改善 24 h-ABP 控制。