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Skin deep: The decoupling of genetic admixture levels from phenotypes that differed between source populations
American Journal of Physical Anthropology ( IF 2.6 ) Pub Date : 2021-03-27 , DOI: 10.1002/ajpa.24261
Jaehee Kim 1 , Michael D Edge 2 , Amy Goldberg 3 , Noah A Rosenberg 1
Affiliation  

In genetic admixture processes, source groups for an admixed population possess distinct patterns of genotype and phenotype at the onset of admixture. Particularly in the context of recent and ongoing admixture, such differences are sometimes taken to serve as markers of ancestry for individuals—that is, phenotypes initially associated with the ancestral background in one source population are assumed to continue to reflect ancestry in that population. Such phenotypes might possess ongoing significance in social categorizations of individuals, owing in part to perceived continuing correlations with ancestry. However, genotypes or phenotypes initially associated with ancestry in one specific source population have been seen to decouple from overall admixture levels, so that they no longer serve as proxies for genetic ancestry. Here, we aim to develop an understanding of the joint dynamics of admixture levels and phenotype distributions in an admixed population.

中文翻译:

肤浅:遗传混合水平与源种群之间不同的表型脱钩

在遗传混合过程中,混合种群的源组在混合开始时具有不同的基因型和表型模式。特别是在最近和正在进行的混合的背景下,这种差异有时被认为是个体祖先的标志——也就是说,最初与一个来源人群中的祖先背景相关的表型被假定为继续反映该人群中的祖先。这种表型可能在个体的社会分类中具有持续的重要性,部分原因是感知到与祖先的持续相关性。然而,最初与一个特定来源群体中的祖先相关的基因型或表型已被认为与整体混合水平脱钩,因此它们不再充当遗传祖先的代理。这里,
更新日期:2021-05-22
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