In the current study, via applying a hybrid-ligand method, a novel Cu(II)-based coordination polymer, formulated as [Cu₂(OH)(bib)(bpt)]·H₂O (1) (H₃bpt = biphenyl-3,4′,5-tricarboxylic acid, bib = 1,4-bis(1-imidazolyl)benzene), has been successfully obtained by a isothermal method. Its treatment effect against postpartum hemorrhage was assessed in the bio-study. Firstly, through the model establishment and compound treatment, the prothrombin activity in the plasma was assessed by measuring the prothrombin time. Next, the levels of the factor XI and IX were also assessed by ELISA (enzyme linked immunosorbent assay detection kit). In addition to this, the prevention activity of the compound on the disseminated intravascular coagulation (DIC) during postpartum hemorrhage was also evaluated by measuring the inflammatory response of the inflammatory cytokines, such as IL-1β (interleukin-1β) and TNF-α (tumor necrosis factor-α). The inflammatory signaling relative expression was assessed via the real time RT-PCR (reverse transcription-polymerase chain reaction) as well. Above all, we can see that the compound has excellent treatment activity on DIC disease by inhibiting p53 and nf-κb relative expression in the endothelial cells.

在当前的研究中，通过应用混合配体方法，一种新型的基于Cu（II）的配位聚合物被配制为[Cu ₂（OH）（bib）（bpt）]·H ₂ O（1）（H ₃已经通过等温方法成功地获得了bpt =联苯-3,4'，5-三羧酸，bib = 1,4-双（1-咪唑基）苯。在生物研究中评估了其对产后出血的治疗效果。首先，通过模型建立和化合物处理，通过测量凝血酶原时间来评估血浆中的凝血酶原活性。接下来，还通过ELISA（酶联免疫吸附测定检测试剂盒）评估了因子XI和IX的水平。除此之外，还通过测量炎症细胞因子如IL-1β（白介素-1β）和TNF-α（肿瘤坏死因子-α）。还通过实时RT-PCR（逆转录-聚合酶链反应）评估了炎症信号的相对表达。最重要的是，我们可以看到该化合物通过抑制DIC疾病具有出色的治疗活性。p53和nf-κb在内皮细胞中的相对表达。