: Sarcopenia, defined as decreased muscle mass or function, is prevalent in chronic kidney disease (CKD) increasing the risk of mobility impairment and frailty. CKD leads to metabolic acidosis (MA) and retention of uremic toxins contributing to insulin resistance and impaired muscle mitochondrial energetics. Here we focus on the central role of muscle mitochondrial metabolism in muscle function.

中文翻译：

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对慢性肾病和代谢性酸中毒中肌肉功能的新见解。

：肌肉减少症，定义为肌肉质量或功能下降，在慢性肾病 (CKD) 中很普遍，会增加活动障碍和虚弱的风险。CKD 导致代谢性酸中毒 (MA) 和尿毒症毒素滞留，导致胰岛素抵抗和肌肉线粒体能量受损。在这里，我们关注肌肉线粒体代谢在肌肉功能中的核心作用。