Blood coagulation represents one of the most studied processes in biomedical modelling. However, clinical applications of this modelling remain limited because of the complexity of this process and because of large inter-patient variation of the concentrations of blood factors, kinetic constants and physiological conditions. Determination of some of these patients-specific parameters is experimentally possible, but it would be related to excessive time and material costs impossible in clinical practice. We propose in this work a methodological approach to patient-specific modelling of blood coagulation. It begins with conventional thrombin generation tests allowing the determination of parameters of a reduced kinetic model. Next, this model is used to study spatial distributions of blood factors and blood coagulation in flow, and to evaluate the results of medical treatment of blood coagulation disorders.

血液凝固是生物医学建模中研究最多的过程之一。然而，由于该过程的复杂性以及患者间血液因子浓度、动力学常数和生理条件的巨大差异，该模型的临床应用仍然受到限制。确定这些患者特定参数中的一些在实验上是可能的，但这与临床实践中不可能的过多时间和材料成本有关。我们在这项工作中提出了一种针对患者特异性凝血模型的方法学方法。它从传统的凝血酶生成测试开始，允许确定减少的动力学模型的参数。接下来，该模型用于研究血流中血液因子和凝血的空间分布，