Endocrine-disrupting chemicals (EDCs) are natural or synthetic substances able to mimic, interfere with, or block endogenous hormones, thus disrupting the normal function of the endocrine system. Most of them are largely applied in agriculture and industry. As a result, humans are chronically exposed to mixtures of EDCs. Their adverse effect on human health may appear long after exposure, making it difficult to assess their full impact. Thus, understanding the molecular basis of recognition of suspected EDCs by their biological targets is fundamental to get insight into their mechanism of action. This review will focus on the role of intermolecular interactions, specifically halogen and chalcogen bonds, in EDC recognition processes, offering an overview of the latest advances in the study of disruption mechanisms.

破坏内分泌的化学物质（EDC）是能够模仿，干扰或阻断内源激素，从而破坏内分泌系统正常功能的天然或合成物质。它们中的大多数被广泛应用于农业和工业。结果，人类长期暴露于EDC的混合物中。它们对人体健康的不利影响可能会在暴露后很长时间出现，因此很难评估其全部影响。因此，了解通过其生物学目标识别可疑EDC的分子基础是深入了解其作用机理的基础。这篇综述将重点关注分子间相互作用，特别是卤素和硫族元素键在EDC识别过程中的作用，概述破坏机理研究的最新进展。