Molecular detection of SARS-CoV-2 being challenged by virus variation and asymptomatic infection,Journal of Pharmaceutical Analysis

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Molecular detection of SARS-CoV-2 being challenged by virus variation and asymptomatic infection
Journal of Pharmaceutical Analysis ( IF 6.1 ) Pub Date : 2021-03-26 , DOI: 10.1016/j.jpha.2021.03.006
Congshan Jiang _{1,

2} , Xiaowei Li _{1,

2} , Changrong Ge ₃ , Yuanyuan Ding ₄ , Tao Zhang ₄ , Shuai Cao ₅ , Liesu Meng _{1,

2} , Shemin Lu _{1,

2}

Affiliation

Coronavirus disease 2019 (COVID-19) has been a pandemic for more than a year. With the expanding second wave of the pandemic in winter, the continuous evolution of SARS-CoV-2 has brought new issues, including the significance of virus mutations in infection and the detection of asymptomatic infection. In this review, we first introduced several major SARS-CoV-2 mutations since the COVID-19 outbreak and then mentioned the widely used molecular detection techniques to diagnose COVID-19, primarily focusing on their strengths and limitations. We further discussed the effects of viral genetic variation and asymptomatic infection on the molecular detection of SARS-CoV-2 infection. The review finally summarized useful insights into the molecular diagnosis of COVID-19 under the special situation being challenged by virus mutation and asymptomatic infection.

中文翻译：

SARS-CoV-2的分子检测面临病毒变异和无症状感染的挑战

2019 年冠状病毒病 (COVID-19) 已经流行一年多了。随着冬季第二波疫情的扩大，SARS-CoV-2的不断进化带来了新的问题，包括病毒突变在感染中的意义以及无症状感染者的检测。在这篇综述中，我们首先介绍了自 COVID-19 爆发以来的几种主要 SARS-CoV-2 突变，然后提到了广泛使用的诊断 COVID-19 的分子检测技术，主要关注其优点和局限性。我们进一步讨论了病毒遗传变异和无症状感染对SARS-CoV-2感染分子检测的影响。该综述最终总结了在病毒变异和无症状感染者挑战的特殊情况下，对COVID-19分子诊断的有益见解。

更新日期：2021-03-26

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