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The long shadow of childhood trauma for depression in midlife: examining daily psychological stress processes as a persistent risk pathway
Psychological Medicine ( IF 5.9 ) Pub Date : 2021-03-26 , DOI: 10.1017/s0033291721000921
Stefanie E Mayer 1 , Agus Surachman 2, 3 , Aric A Prather 1 , Eli Puterman 4 , Kevin L Delucchi 1 , Michael R Irwin 5 , Andrea Danese 6, 7 , David M Almeida 2, 3 , Elissa S Epel 1
Affiliation  

Background

Childhood trauma (CT) increases the risk of adult depression. Buffering effects require an understanding of the underlying persistent risk pathways. This study examined whether daily psychological stress processes – how an individual interprets and affectively responds to minor everyday events – mediate the effect of CT on adult depressive symptoms.

Methods

Middle-aged women (N = 183) reported CT at baseline and completed daily diaries of threat appraisals and negative evening affect for 7 days at baseline, 9, and 18 months. Depressive symptoms were measured across the 1.5-year period. Mediation was examined using multilevel structural equation modeling.

Results

Reported CT predicted greater depressive symptoms over the 1.5-year time period (estimate = 0.27, s.e. = 0.07, 95% CI 0.15–0.38, p < 0.001). Daily threat appraisals and negative affect mediated the effect of reported CT on depressive symptoms (estimate = 0.34, s.e. = 0.08, 95% CI 0.22–0.46, p < 0.001). Daily threat appraisals explained more than half of this effect (estimate = 0.19, s.e. = 0.07, 95% CI 0.08–0.30, p = 0.004). Post hoc analyses in individuals who reported at least moderate severity of CT showed that lower threat appraisals buffered depressive symptoms. A similar pattern was found in individuals who reported no/low severity of CT.

Conclusions

A reported history of CT acts as a latent vulnerability, exaggerating threat appraisals of everyday events, which trigger greater negative evening affect – processes that have important mental health consequences and may provide malleable intervention targets.



中文翻译:


童年创伤对中年抑郁症的长期影响:将日常心理压力过程视为持续的风险途径


 背景


童年创伤(CT)会增加成年抑郁症的风险。缓冲效应需要了解潜在的持续风险路径。这项研究检验了日常心理压力过程(个人如何解释和情感地应对日常小事件)是否会介导 CT 对成人抑郁症状的影响。

 方法


中年女性 ( N = 183) 在基线时报告了 CT,并在基线时 7 天、第 9 个月和第 18 个月完成了威胁评估和负面夜间情绪的每日日记。对 1.5 年期间的抑郁症状进行了测量。使用多级结构方程模型检查中介作用。

 结果


报告的 CT 预测 1.5 年期间抑郁症状会加重(估计值 = 0.27, se = 0.07,95% CI 0.15–0.38, p < 0.001)。每日威胁评估和负面情绪介导了报告的 CT 对抑郁症状的影响(估计值 = 0.34, se = 0.08,95% CI 0.22–0.46, p < 0.001)。每日威胁评估解释了一半以上的影响(估计值 = 0.19, se = 0.07,95% CI 0.08–0.30, p = 0.004)。对报告至少中度 CT 严重程度的个体进行事后分析表明,较低的威胁评估可以缓解抑郁症状。在报告没有或轻度 CT 严重程度的个体中也发现了类似的模式。

 结论


报告的 CT 历史充当了潜在的脆弱性,夸大了对日常事件的威胁评估,从而引发更大的负面夜间影响,这些过程会产生重要的心理健康后果,并可能提供可塑的干预目标。

更新日期:2021-03-26
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