Adolescent risk for self-injurious thoughts and behaviors (STBs) involves disturbance across multiple systems (e.g., affective valence, arousal regulatory, cognitive and social processes). However, research integrating information across these systems is lacking. Utilizing a multiple-levels-of-analysis approach, this person-centered study identified psychobiological stress response profiles and linked them to cognitive processes, interpersonal behaviors, and STBs. At baseline, adolescent girls (N = 241, Mage = 14.68 years, Range = 12–17) at risk for STBs completed the Trier Social Stress Test (TSST), questionnaires, and STB interviews. Positive affect (PA), negative affect (NA), and salivary cortisol (SC) were assessed before and after the TSST. STBs were assessed again during 3, 6, and 9 month follow-up interviews. Multitrajectory modeling of girls’ PA, NA, and SC revealed four profiles, which were compared on cognitive and behavioral correlates as well as STB outcomes. Relative to normative, girls in the affective distress, hyperresponsive, and hyporesponsive subgroups were more likely to report negative cognitive style (all three groups) and excessive reassurance seeking (hyporesponsive only) at baseline, as well as nonsuicidal self-injury (all three groups) and suicidal ideation and attempt (hyporesponsive only) at follow-up. Girls’ close friendship characteristics moderated several profile–STB links. A synthesis of the findings is presented alongside implications for person-centered tailoring of intervention efforts.

自我伤害思想和行为 (STB) 的青少年风险涉及跨多个系统的干扰（例如，情感效价、唤醒调节、认知和社会过程）。然而，缺乏跨这些系统整合信息的研究。利用多层次分析方法，这项以人为本的研究确定了心理生物学压力反应概况，并将它们与认知过程、人际关系行为和 STB 联系起来。基线时，青春期女孩（N = 241，M年龄= 14.68 岁，范围 =12–17) 有 STB 风险的人完成了特里尔社会压力测试 (TSST)、问卷调查和 STB 访谈。在 TSST 之前和之后评估了积极影响 (PA)、消极影响 (NA) 和唾液皮质醇 (SC)。在 3、6 和 9 个月的后续访谈中再次评估 STB。女孩 PA、NA 和 SC 的多轨迹建模揭示了四个概况，这些概况在认知和行为相关性以及 STB 结果上进行了比较。相对于正常情况，处于情感困扰、反应过度和反应迟钝亚组的女孩更有可能报告消极认知风格（所有三组）和过度寻求安慰（反应迟钝仅）在基线时，以及非自杀性自伤（所有三组）和自杀意念和企图（仅反应迟钝）在后续行动中。女孩的亲密友谊特征调节了几个 profile-STB 链接。对调查结果的综合介绍以及对以人为本的干预工作调整的影响。