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Green synthesis of nickel oxide nanoparticles using leaf extract of Berberis balochistanica: Characterization, and diverse biological applications
Microscopy Research and Technique ( IF 2.0 ) Pub Date : 2021-03-25 , DOI: 10.1002/jemt.23756
Siraj Uddin 1, 2 , Luqman Bin Safdar 1, 3 , Javed Iqbal 1, 4 , Tabassum Yaseen 4 , Sabiha Laila 5 , Saeed Anwar 1 , Banzeer Ahsan Abbasi 1 , Muhammad Saqib Saif 6 , Umar Masood Quraishi 1
Affiliation  

In current report, nickel oxide nanoparticles (NiONPs) were synthesized using leaf extract of Berberis balochistanica (BB) an endemic medicinal plant. The BB leaves extract act as a strong reducing, stabilizing, and capping agent in the synthesis of BB@NiONPs. Further, BB@NiONPs were characterized using Uv–visible spectroscopy (UV–vis), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Energy dispersive spectroscopy (EDS), scanning electron microscopy (SEM), and average size was calculated ~21.7 nm). Multiple in vitro biological activities were performed to determine their therapeutic potentials. The BB@NiONPs showed strong antioxidant activities in term of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and total antioxidant capacity (TAC) with scavenging potential of 69.98 and 59.59% at 200 μg/ml, respectively. The antibacterial and antifungal testes were examined using different bacterial and fungal strains and dose-dependent inhibition response was reported. Laterally, cytotoxic and phytotoxic activities were studied using brine shrimp and radish seeds. The result determined potential cytotoxic activity with LD50 value (49.10 μg/ml) and outstanding stimulatory effect of BB@NiONPs on seed germination at lower concentrations as compared to control. Overall, result concluded that biosynthesis of NiONPs using leaf extracts of Berberis balochistanica is cheap, easy, and safe method and could be used in biomedical and agriculture field as nanomedicine and nano fertilizer.

中文翻译:

使用小檗叶提取物绿色合成氧化镍纳米颗粒:表征和多种生物应用

在目前的报告中,氧化镍纳米粒子 (NiONPs) 是使用小檗叶提取物合成的(BB) 一种地方性药用植物。BB 叶提取物在 BB@NiONPs 的合成中充当强还原剂、稳定剂和封端剂。此外,BB@NiONPs 使用紫外-可见光谱 (UV-vis)、X 射线衍射 (XRD)、傅里叶变换红外光谱 (FT-IR)、能量色散光谱 (EDS)、扫描电子显微镜 (SEM)、平均尺寸计算为~21.7 nm)。进行了多种体外生物活性以确定它们的治疗潜力。BB@NiONPs 在 2,2-diphenyl-1-picrylhydrazyl (DPPH) 和总抗氧化能力 (TAC) 方面表现出很强的抗氧化活性,在 200 μg/ml 时的清除能力分别为 69.98% 和 59.59%。使用不同的细菌和真菌菌株检查了抗菌和抗真菌睾丸,并报告了剂量依赖性抑制反应。横向地,使用盐水虾和萝卜种子研究了细胞毒性和植物毒性活性。结果确定了 LD 的潜在细胞毒活性50值 (49.10 μg/ml) 和 BB@NiONPs 在较低浓度下对种子萌发的显着刺激作用与对照相比。总体而言,结果表明使用小檗叶提取物生物合成 NiONPs是一种廉价、简单、安全的方法,可作为纳米医学和纳米肥料用于生物医学和农业领域。
更新日期:2021-03-25
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