Our aim was to analyse the associations between carotid plaque burden (CPB), cardiovascular risk factors (CVRF), and surrogate markers of CV risk in subjects with metabolic syndrome (MetS). We consecutively included 75 asymptomatic outpatients with MetS components, <60 years old and non-smokers. We determined the presence of CVRF, left ventricular hypertrophy (LVH), carotid intima-media thickness (cIMT), albumin-creatinine ratio (ACR), coronary artery calcium score (CACS) and CPB by 3-dimensional vascular ultrasound (3DVUS) for comparison. A total of 50 (67%) subjects had MetS defined by harmonized criteria. A CPB >0 mm³ and a CACS >0 AU were the risk biomarkers most frequently observed (72% and 77%, respectively), followed by LVH (40%). CPB and CACS revealed association with cardiovascular risk (r = 0.308; p = 0.032 and r = 0.601 p < 0.01, respectively), and CPB also showed association with the burden of CVRF (r = 0.349; p = 0.014). CPB by 3DVUS was a prevalent CV risk marker, directly associated with CVRF and cardiovascular risk in MetS subjects.

Graphical abstract

中文翻译：

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3 维血管超声检测颈动脉斑块负担作为代谢综合征患者的风险标志物

我们的目的是分析颈动脉斑块负荷 (CPB)、心血管危险因素 (CVRF) 和代谢综合征 (MetS) 受试者心血管风险的替代标志物之间的关联。我们连续纳入了 75 名具有 MetS 成分的无症状门诊患者，年龄小于 60 岁且不吸烟。我们通过 3 维血管超声 (3DVUS) 确定了 CVRF、左心室肥厚 (LVH)、颈动脉内膜中层厚度 (cIMT)、白蛋白肌酐比 (ACR)、冠状动脉钙化评分 (CACS) 和 CPB 的存在。比较。共有 50 名 (67%) 受试者具有由统一标准定义的 MetS。CPB >0 mm ³和 CACS >0 AU 是最常观察到的风险生物标志物（分别为 72% 和 77%），其次是 LVH（40%）。CPB 和 CACS 显示与心血管风险相关（r = 0.308；p = 0.032 和r = 0.601 p < 0.01），CPB 也显示出与 CVRF 负担相关（r = 0.349；p = 0.014）。3DVUS 的 CPB 是一种普遍的 CV 风险标志物，与 MetS 受试者的 CVRF 和心血管风险直接相关。

图形概要