Enhancer reprogramming lies at the heart of dynamic cellular processes such as differentiation and tumorigenesis. WNT signaling is an evolutionary conserved pathway that exploits transcriptional enhancers to control the state-specific transcriptional program. Recent evidences suggest several mechanisms that govern this state-specific enhancer regulation in stem cells and cancer.

中文翻译：

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WNT 调节的转录增强子和干细胞可塑性

增强子重编程是动态细胞过程（如分化和肿瘤发生）的核心。WNT 信号是一种进化保守的途径，它利用转录增强子来控制状态特定的转录程序。最近的证据表明，有几种机制可以控制干细胞和癌症中的这种状态特异性增强子调节。