Parkinson’s disease (PD), a common neurodegenerative motor disorder characterized by striatal dopaminergic neuronal loss and localized neuroinflammation in the midbrain region. Activation of microglia is associated with various inflammatory mediators and Kynurenine pathway (KP) being one of the major regulator of immune response, is involved in the neuroinflammatory and neurotoxic cascade in PD. In the current study, 1-Methyltryptophan (1-MT), an Indolamine-2,3-dioxygenase-1 (IDO-1) inhibitor was tested at different doses (2.5 mg/kg, 5 mg/kg and 10 mg/kg) for its effect on behavioral parameters, oxidative stress, neuroinflammation, apoptosis, mitochondrial dysfunction, neurotransmitter levels, biochemical and behavioral alterations in unilateral 6-OHDA (3 μg/μL) murine model of PD. The results showed improved locomotion in open field test and motor coordination in rota-rod, reduced oxidative stress, neuroinflammatory markers (TNF-α, IFN-γ, IL-6), mitochondrial dysfunction and neuronal apoptosis (caspase-3). Also, restoration of neurotransmitter levels (dopamine and homovanillic acid) in the striatum and increased striatal BDNF levels were observed. Overall findings suggest that 1-MT could be a potential candidate for further studies to explore its possibility as an alternative in the pharmacotherapy of PD.

帕金森病 (PD)，一种常见的神经退行性运动障碍，其特征是纹状体多巴胺能神经元丢失和中脑区域的局部神经炎症。小胶质细胞的激活与各种炎症介质有关，犬尿氨酸通路 (KP) 是免疫反应的主要调节剂之一，参与 PD 的神经炎症和神经毒性级联反应。在当前的研究中，1-甲基色氨酸 (1-MT)，一种 Indolamine-2,3-dioxygenase-1 (IDO-1) 抑制剂在不同剂量下进行了测试（2.5 mg/kg、5 mg/kg 和 10 mg/kg ) 对 PD 的单侧 6-OHDA (3 μg/μL) 小鼠模型的行为参数、氧化应激、神经炎症、细胞凋亡、线粒体功能障碍、神经递质水平、生化和行为改变的影响。结果表明，在露天试验中运动和旋转杆的运动协调性得到改善，氧化应激、神经炎症标志物（TNF-α、IFN-γ、IL-6）、线粒体功能障碍和神经元凋亡（caspase-3）减少。此外，还观察到纹状体中神经递质水平（多巴胺和高香草酸）的恢复和纹状体 BDNF 水平的增加。总体研究结果表明，1-MT 可能是进一步研究的潜在候选者，以探索其作为 PD 药物治疗替代方案的可能性。