Periodontitis‐compromised dental pulp stem cells secrete extracellular vesicles carrying miRNA‐378a promote local angiogenesis by targeting Sufu to activate the Hedgehog/Gli1 signalling,Cell Proliferation

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Periodontitis‐compromised dental pulp stem cells secrete extracellular vesicles carrying miRNA‐378a promote local angiogenesis by targeting Sufu to activate the Hedgehog/Gli1 signalling
Cell Proliferation ( IF 5.9 ) Pub Date : 2021-03-23 , DOI: 10.1111/cpr.13026
Huan Zhou _{1,

2} , Xuan Li ₁ , Rui-Xin Wu ₁ , Xiao-Tao He ₁ , Ying An ₁ , Xin-Yue Xu _{1,

2} , Hai-Hua Sun ₁ , Li-An Wu ₁ , Fa-Ming Chen ₁

Affiliation

Previously, our investigations demonstrated robust pro‐angiogenic potentials of extracellular vesicles secreted by periodontitis‐compromised dental pulp stem cells (P‐EVs) when compared to those from healthy DPSCs (H‐EVs), but the underlying mechanism remains unknown.

中文翻译：

牙周炎受损的牙髓干细胞分泌携带 miRNA-378a 的细胞外囊泡，通过靶向 Sufu 激活 Hedgehog/Gli1 信号传导促进局部血管生成

此前，我们的研究表明，与健康 DPSCs (H-EVs) 相比，牙周炎受损牙髓干细胞 (P-EVs) 分泌的细胞外囊泡具有强大的促血管生成潜力，但其潜在机制仍不清楚。

更新日期：2021-05-02

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