In the course of screening for new antimicrobial compounds, a new antibiotic substance named saccharobipyrimicin was isolated from the leaf-litter actinomycete Saccharothrix sp. MM696L-181F4. The structure of saccharobipyrimicin was elucidated by various spectral methods, mainly single-crystal X-ray analysis and chemical degradation. It revealed that saccharobipyrimicin contained a 2,2′-bipyridine skeletal structure. Saccharobipyrimicin showed moderate and broad-spectrum antimicrobial activity. Two chemical derivatives of saccharobipyrimicin showed weaker antimicrobial activities than that of saccharobipyrimicin against most test microorganisms except two tolC mutants of Escherichia coli and Neisseria gonorrhoeae.

在筛选新的抗菌化合物的过程中，从落叶放线菌Saccharothrix sp. 中分离出了一种名为糖尿嘧啶的新型抗菌物质。MM696L-181F4。通过各种光谱方法，主要是单晶X射线分析和化学降解，阐明了糖双嘧啶的结构。结果表明糖二嘧啶含有2,2'-联吡啶骨架结构。Saccharobipiricin 显示出中等和广谱的抗菌活性。除了大肠杆菌和淋病奈瑟菌的两个tolC突变体外，糖嘧啶的两种化学衍生物对大多数试验微生物的抗菌活性都比糖嘧啶弱。