Acute infections are associated with an elevated cardiovascular risk. However, little is known about the interactions of acute inflammatory responses and the cardiovascular system. We therefore aimed to evaluate effects of acute inflammatory stimuli mediated by LPS administration on a set of 89 cardiovascular biomarkers. A single-blinded, placebo-controlled cross-over study using the human endotoxin model was performed. Ten healthy men were administered lipopolysaccharide (LPS) or placebo on two different study days after an overnight fast. Eighty-nine different cardiovascular biomarkers were measured repetitively over 48 h. Out of 89 cardiovascular biomarkers, 54 markers were significantly influenced by LPS infusion. The observed biomarker response to inflammation was more pronounced and complex than anticipated. In conclusion, our data show that the cardiovascular system is under enormous distress in response to experimental low-dose inflammation in humans, as demonstrated by a significant effect on 54 of the 89 biomarkers tested.

急性感染与心血管风险升高有关。然而，关于急性炎症反应和心血管系统的相互作用知之甚少。因此，我们旨在评估 LPS 给药介导的急性炎症刺激对一组 89 种心血管生物标志物的影响。使用人类内毒素模型进行了一项单盲、安慰剂对照的交叉研究。十名健康男性在禁食后的两个不同的研究日内服用脂多糖 (LPS) 或安慰剂。在 48 小时内重复测量了 89 种不同的心血管生物标志物。在 89 个心血管生物标志物中，54 个标志物受到 LPS 输注的显着影响。观察到的对炎症的生物标志物反应比预期的更为明显和复杂。综上所述，