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Lateral ventricular liponeurocytoma: Review of literature and case illustration
Neurochirurgie ( IF 1.5 ) Pub Date : 2021-03-22 , DOI: 10.1016/j.neuchi.2021.03.004
M R Al-Umran 1 , S R Al-Umran 2 , A F Arab 2 , M A Dababo 3 , F A Alotaibi 4
Affiliation  

Background

Liponeurocytoma is an uncommon tumor of the central nervous system. It is very rare for this tumor to originate within the lateral ventricle. In the context of the rarity of this tumor entity, this review article aims to summarize the clinical, radiological, and pathological features of lateral ventricular liponeurocytoma to facilitate its diagnosis and management.

Methods

Here, we conduct a systematic literature review using the Pubmed, Scopus, and Cochrane Library database for all cases of lateral ventricular liponeurocytoma. A case illustration complements this review.

Results

The described cases from 1997 onward include 14 cases that have been published in full papers in the English literature. Six additional cases are reported in short English abstracts in full non-English papers, and one case was described in a central neurocytoma report. There is a definite male predominance of 70% (14 male) and a mean age of 37 years (range 24–62). Heterogenous enhancement and signals in magnetic resonant images (MRI) are the radiological characteristics. In all reported cases, the presence of lipocytes and fat vacuoles is considered the paramount histopathological feature. Total surgical resection was achieved in 80% (12 out of 15) of the cases. Only two cases (including ours) received radiation therapy. Recurrence was seen in two patients during follow-up that was treated by radiation therapy in one and surgery in the other. The proliferation index is mostly below 5% in all cases, with the Ki-67 range between < 1% to 10%.

Conclusions

Lateral ventricular liponeurocytoma has been treated effectively by surgical resection in a limited number of cases. The decision for radiation therapy is based on a high proliferation index and tumor recurrence.



中文翻译:

侧脑室脂肪神经细胞瘤:文献复习和病例说明

背景

脂肪神经细胞瘤是一种罕见的中枢神经系统肿瘤。这种肿瘤起源于侧脑室内的情况非常罕见。在这种肿瘤实体罕见的背景下,这篇综述文章旨在总结侧脑室脂肪神经细胞瘤的临床、放射学和病理学特征,以促进其诊断和治疗。

方法

在这里,我们使用 Pubmed、Scopus 和 Cochrane 图书馆数据库对所有侧脑室脂肪神经细胞瘤病例进​​行了系统的文献回顾。案例说明补充了本评论。

结果

从 1997 年起所描述的案例包括 14 个已在英文文献中全文发表的案例。在完整的非英语论文中,以简短的英文摘要形式报告了另外 6 例病例,并在中枢神经细胞瘤报告中描述了 1 例病例。70% 的男性占绝对优势(14 名男性),平均年龄为 37 岁(范围 24-62)。磁共振图像 (MRI) 中的异质增强和信号是放射学特征。在所有报告的病例中,脂肪细胞和脂肪泡的存在被认为是最重要的组织病理学特征。80% 的病例(15 例中的 12 例)实现了完全手术切除。只有两个病例(包括我们的)接受了放射治疗。两名患者在随访期间出现复发,其中一名接受放射治疗,另一名接受手术治疗。 <  1% 到 10%。

结论

在少数病例中,通过手术切除有效治疗了侧脑室脂肪神经细胞瘤。放射治疗的决定是基于高增殖指数和肿瘤复发。

更新日期:2021-03-22
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